|Title||Distinct microbiome-neuroimmune signatures correlate with functional abdominal pain in children with autism spectrum disorder|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Luna, RAnn, Oezguen, N, Balderas, M, Venkatachalam, A, Runge, JK, Versalovic, J, Veenstra-VanderWeele, J, Anderson, GM, Savidge, T, Williams, K|
|Journal||Cellular and Molecular Gastroenterology and Hepatology|
Study Aims and Objectives
Methods - Sample, Procedure, Study Measures, Analysis This study looked at samples of blood and intestinal tissue that were taken during colonoscopies of boys and girls aged 3 to 18. The type of bacteria and various small proteins that play a role in communication between the gut and brain were compared between children with ASD and neurotypically developing children.
Results – Main Finding(s) The type of bacteria differed between children with ASD and neurotypically developing children. Further differences in the type of bacteria were seen between children with ASD who were experiencing abdominal pain and neurotypical children who reported abdominal pain. The differences in bacteria associated with abdominal pain in children with ASD were also associated with differences in the type of small proteins that play a role in communications between the gastrointestinal, immune, and nervous system.
Conclusion – Summary Statements